Some school districts report that substitute teachers are staying away, wary of returning to the classroom at a time when COVID-19 cases are spiking across the state and nation.

The Indiana State Department of Health reported 230 additional confirmed deaths over the last week, bringing the state's total to 4,124 -- the largest reported in a single week since mid-May.

Gov. Eric Holcomb insists Hoosiers are safe at polling places across the state amid the ongoing pandemic. That's despite a record new number of COVID-19 cases, long lines at the polls and some county clerks who refuse to follow Holcomb's mask-wearing order.

Enrollment at Indianapolis Public Schools is down nearly 4 percent compared to last fall and the lowest since 201617, according to an update from district leaders ahead of the state releasing official data.

In Indiana, domestic violence calls and domestic violence deaths are on the rise. Advocates say the increase is directly related to coronavirus. The Indiana Coalition Against Domestic Violence reports an 86 percent increase in domestic violence-related deaths.

The U.S. government has agreed to purchase 300,000 doses of Eli Lillys COVID-19 antibody treatment. It plans to pay $375 million for the vials of the drug.

Indiana's 3,649 new cases is the eighth one-day record set since the state moved to Stage 5 of its reopening plan.

During the month of October, Marion Countys COVID positivity rate crept up to nearly seven percent. The number of new daily cases has risen to more than 200 a day.

The Indiana State Department of Health reported Thursday its 4,000th death since the beginning of the coronavirus pandemic. After a late summer lull, the rate has picked up as cases have increased.

The Indiana State Department of Health on Wednesday again increased the number of counties designated as higher-risk locations for coronavirus spread.